anthra[1,9-cd]pyrazol-6(2H)-one
anthra[1,9-cd]pyrazol-6(2H)-one
CAS: 129-56-6
Molecular Formula: C14H8N2O
anthra[1,9-cd]pyrazol-6(2H)-one - Names and Identifiers
| Name | anthra[1,9-cd]pyrazol-6(2H)-one |
| Synonyms | SP600125 NSC75890 Nsc75890 c.i.70300 SP 600125 SP-600125 C.I. 70300 pyrazolanthrone 1,9-Pyrazoloanthrone 4-aminobenzenesulfonamide Dibenzo[cd,g]indazol-6(2H)-one dibenzo[cd,g]indazol-6(2H)-one Anthra(1,9-cd)pyrazol-6(2h)-one anthra[1,9-cd]pyrazol-6(2H)-one JNK Inhibitor II, 1,9-Pyrazoloanthrone |
| CAS | 129-56-6 |
| EINECS | 204-955-6 |
| InChI | InChI=1/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) |
| InChIKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
anthra[1,9-cd]pyrazol-6(2H)-one - Physico-chemical Properties
| Molecular Formula | C14H8N2O |
| Molar Mass | 220.23 |
| Density | 1.1702 (rough estimate) |
| Melting Point | 281~282℃ |
| Boling Point | 361.16°C (rough estimate) |
| Flash Point | 246.8°C |
| Solubility | H2O: insoluble |
| Vapor Presure | 1.01E-09mmHg at 25°C |
| Appearance | Yellow |
| Color | yellow |
| pKa | 11.75±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| Refractive Index | 1.5910 (estimate) |
| MDL | MFCD00022289 |
| Physical and Chemical Properties | Character yellow or dark yellow powder. Melting Point: 281-282 ℃ |
| Use | Used as dye intermediates, can be used to produce reduced ash M, etc |
| In vitro study | SP600125 is an ATP-competitive c-Jun N-terminal kinase (JNK) selective inhibitor with an IC50 of 40 nM to 90 nM. SP600125 acts on Jurkat T cells and inhibits c-Jun phosphorylation with an IC50 of 5 μm to 10 μm. SP600125 acts on CD4 However, later studies have shown that SP600125 also inhibits the aromatic hydrocarbon receptor (AhR) Mps1, and A series of other serine/threonine kinases, including Aurora kinase A, FLT3, MELK, and TRKA. 20 μm SP600125 acts on mouse beta cells MIN6 to induce p38 MAPK phosphorylation and its downstream CREB-dependent promoter activation. 20 μm SP600125 acts on HCT116 cells to stop mitosis at G2 phase and induce intranuclear replication. |
| In vivo study | SP600125 at 15 mg/kg or 30 mg/kg significantly inhibited lipopolysaccharide (LPS)-induced TNF-α expression and CD4 induced by CD3 antibody in mice |
anthra[1,9-cd]pyrazol-6(2H)-one - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | CB4585000 |
| TSCA | Yes |
| HS Code | 29339900 |
| Toxicity | LD50 ivn-mus: 178 mg/kg CSLNX* NX#00640 |
anthra[1,9-cd]pyrazol-6(2H)-one - Upstream Downstream Industry
| Raw Materials | Sodium nitrite 1-Aminoanthraquinone |
anthra[1,9-cd]pyrazol-6(2H)-one - Reference
| Reference Show more | 1. [IF=4.396] Xiaoman Chen et al."Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells."Mol Pharmaceut. 2018;15(11):4974–4984 2. [IF=3.375] Tian Gao et al."Use of Saikosaponin D and JNK inhibitor SP600125, alone or in combination, inhibits malignant properties of human osteosarcoma U2 cells."Am J Transl Res. 2019; 11(4): 2070–2080 |
anthra[1,9-cd]pyrazol-6(2H)-one - Introduction
1,9-PYRAZOLOANTHRONE
Last Update：2022-10-16 17:13:07
anthra[1,9-cd]pyrazol-6(2H)-one - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor that acts on JNK1, JNK2 and JNK3. IC50 in cell-free test is 40 nM, 40 nM and 90 nM respectively, which is 10 times higher than that on MKK4 and 25 times higher than that on MKK3, MKK6, PKB and PKCα, it is 100 times more selective than ERK2, p38, Chk1, EGFR, etc. SP600125 is also a broad-spectrum serine/threonine kinases inhibitor, including Aurora kinase A, FLT3 and TRKA, with corresponding IC50 values of 60 nM, 90 nM and 70 nM. SP600125 can inhibit autophagy and activate apoptosis. |
| Target | Value |
| serine/threonine kinase () | |
| JNK1 (Cell-free assay) | 40 nM |
| JNK2 (Cell-free assay) | 40 nM |
| Aurora A (Cell-free assay) | 60 nM |
| TrkA (Cell-free assay) | 70 nM |
| Use | Used as a dye intermediate, it can be used to produce reduced ash M, etc. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | vein-mouse LD50: 178 mg/kg |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxide smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-10 22:29:15
![anthra[1,9-cd]pyrazol-6(2H)-one](http://res.chembk.com/assets/str/2d/1/12/129-56-6.png)
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Spot supply
Product Name: 2H-Dibenzo[cd,g]indazol-6-one Visit Supplier Webpage Request for quotationCAS: 129-56-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Raw Materials for anthra[1,9-cd]pyrazol-6(2H)-one